Table of contents
1. Stress and sex hormones
2. Stress and the thyroid
3. Stress and insulin
4. Stress and melatonin
5. Supporting stress resilience
Illustrated by Sabrina Bezerra, Erin Rommel & Ralitza Nikolova
Stress is a normal – and necessary – part of everyday life. But if you’re experiencing chronic stress and high cortisol symptoms you may notice a knock-on effect on your other hormones. Knowing how to lower stress hormones is an essential tool for feeling more balanced in your cycle, and yourself.
Stress gets a pretty bad rap. It’s commonly associated with negative symptoms like poor sleep, anxiety, digestive issues and irritability. And those certainly can be signs of chronic or intense stress. But some stress is essential: an uptick in our stress hormone cortisol is what gets us out of bed in the morning. Appropriate levels of stress also motivate us, fuel our productivity and help us to respond quickly if we’re in danger.
The body’s response to stressors is the same whether they’re physical (a car racing towards us as we cross the road) or psychological (an argument or a short-term work crisis). In these moments, the brain registers the stressor and sends messages via the sympathetic nervous system to the adrenal glands, which pump out adrenaline and cortisol. These stress hormones then activate certain processes in the body, putting it into ‘fight or flight’ mode. The communication process that controls these actions is the hypothalamic-pituitary-adrenal (HPA) axis.

In the ‘fight or flight’ state, you feel more alert and energised; your muscles are tense, your heart-rate is faster and you take quicker breaths. In a normal stress response, once the threat has passed, your parasympathetic nervous system kicks in to calm you down. The stress response’s ability to adapt in this way is healthy and desirable.
However, when stress becomes chronic – when we are living with constant or repetitive stressors – the adaptation of this response is compromised and our other hormones are affected. The cycles these hormones help to regulate can then get out of whack.
Stress and sex hormones
Just as the brain sends messages to the adrenal glands to release stress hormones, it also communicates with the ovaries about which hormones to release at different points in the menstrual cycle.
The brain’s perception of stress affects the communication of these messages, altering the release of the sex hormones oestrogen and progesterone. This can show up as shorter cycles, PMS, anxiety and even missed or absent periods.
Outside of cycle changes, chronic psycho-social stress has been shown to result in reduced libido and female reproductive and sexual function. Dys-regulated sex hormones can also impact mood and the immune system.

Stress and the thyroid
The thyroid is a butterfly-shaped gland in the neck, which produces hormones that control the body’s metabolism.
The thyroid is highly sensitive to stress. Elevated stress hormones can interfere with thyroid hormone production and the conversion of thyroid hormones into their active form. But compromised thyroid hormones can also make you more susceptible to feeling stress, creating a vicious cycle.
Hypothyroidism (low thyroid function) is the most common thyroid dysfunction, and is a slowing down of the body’s metabolic rate. Some of the classic symptoms are fatigue, low mood, anxiety, weight gain or difficulty losing weight, constipation, intolerance to cold and dry skin. Women may also experience menstrual cycle changes and more intense PMS.